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Wednesday, September 8, 2010

Antibiotics and Kidney Disease

Clindamycin: No dose change
Azithromycin: No dose change
Doxycycline: No dose change
Metronidazole: Normal dose for Mild/Mod. disease
Vancomycin Pulvules

Pen VK: Prolong interval
Amoxicillin: Prolong interval
Augmentin: Decrease dose
Ampicillin: Decrease dose
Dicloxacillin: Decrease dose
Keflex: Prolong interval
Duricef: Prolong interval
Clarithromycin: Avoid
Metronidazole: Prolong interval for severe disease
IV Vancomycin: Avoid

a)Serum Creatinine < 2.0 mg/dL or the CrCl is > 50 mL/minute:
Pen VK is dosed normally at 250-500 mg PO q6h
b)S. Creatinine 2.0 mg/dL to Predialysis or CrCl 10-50 mL/minute:
Pen VK is dosed at 250-500 mg q8-12h
c)Patient on Dialysis:
Pen VK is dosed at 250-500 q12-16h


a)Serum Creatinine below 3.3 mg/dL or Cr Cl >30 ml/minute:
Dispense the normal dose of Amoxicillin: 250-500 mg PO q8h
b)Serum Creatinine above 3.3 mg/dL to Predialysis or Cr Cl 10-30 ml/minute:
Prolong the interval and dispense: 250-500 mg PO q12h
Avoid using the 875 mg tablet
c)Cr Cl <10 ml/minute or the Dialysis Patient:
Prolong the interval and dispense: 250-500 mg PO q24h
The dose must be administered after dialysis completion

Decrease the total dosage by 50% in the renal compromised patient

Use full dose of Azithromycin in the Renal compromised patient
Kidney disease: No dose change is needed with Kidney disease or Renal failure
Used with 50% total dose reduction in patient with both Kidney & Liver disease

5)Metronidazole (Flagyl):
Dose adjustment is required only in the presence of renal failure/dialysis
Metronidazole should be dosed at 500 mg PO q12h instead of q8h after the dialysis

6)Tetracycline HCL:
a. Serum Creatinine between 1.25-2.0 mg/dL or CrCl 50-80 mL/minute:
Dose Tetracycline HCL q8-12h
b. Serum Creatinine between 2.0 mg/dL to Pre-dialysis or CrCl 10-50 mL/minute:
Dose Tetracycline HCL q12-24h
c. In the presence of Dialysis or CrCl <10 mL/minute:
Dose Tetracycline HCL q24h

No dose change needed with kidney/live/kidney & liver disease


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Anonymous said...

Very helpful and informative article..Thank you.

Anonymous said...

Went with my husband to the ENT, and showed this to the doctor when he was deciding what antibiotic to give him. He was gonna prescribe amoxicillin, but changed his mind. Thanks for the info.

Anonymous said...

Very helpful and educative keep up the great work

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